Guanine Nucleotide Exchange Factor


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What is Guanine nucleotide exchange factor?

Guanine nucleotide exchange factors (GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP). A variety of unrelated structural domains have been shown to exhibit guanine nucleotide exchange activity. Some GEFs can activate multiple GTPases while others are specific to a single GTPase.

Technology Types



Ephexin5GDP exchange factorGNEFGuanine exchange factorGuanine exchange factorsGuanine nucleotide exchange proteinGuanosine nucleotide exchange factors


Factor intercambiador de nucleótido de guanina (es)Faktor pro výměnu guaninových nukleotidů (cs)Fator de troca de nucleotídeo de guanina (pt)GTP-Austauschfaktoren (de)Guaninnukleotidutbytesfaktor (sv)グアニンヌクレオチド交換因子 (ja)

Tech Info

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 — Date merged: 11/6/2021, 1:33:00 PM
 — Date scraped: 5/20/2021, 6:07:15 PM